Unilateral orbital pain and oculomotor paresis are hallmark features of Tolosa-Hunt Syndrome - a rare cause of painful ophthalmoplegia that demonstrates rapid symptom relief following corticosteroid therapy. Approximately 40% of affected individuals experience recurrence, either ipsilaterally or contralaterally. We present a case of a 60-year-old woman with complaints of left-sided retro-orbital pain accompanied by eyelid drooping and diplopia that had started two weeks prior. Her past and family history were negative. Magnetic resonance imaging of the brain revealed abnormal enlargement of the left cavernous sinus, appearing hypointense on T1WI and hyperintense on T2WI (A, B), with an incidental finding of an empty sella (C). On neurological examination, the patient had hypoesthesia in the trigeminal nerve´s V1 distribution and left ipsilateral third and fourth cranial nerve palsy (D). The enlarged left cavernous sinus showed post-contrast enhancement (E, F) extending through the superior orbital fissure into the orbital apex. The left optic nerve appeared mildly tortuous and enlarged, with intraocular kinking and hyperintensity on T2-weighted images, along with subtle contrast enhancement (G). A comprehensive evaluation ruled out alternative causes involving the cavernous sinus. The patient´s symptoms resolved within 72 hours of initiating corticosteroid therapy, supporting a diagnosis of Tolosa-Hunt Syndrome secondary to idiopathic granulomatous inflammation of the cavernous sinus. She was advised to have regular follow-ups due to the risk of recurrence.

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Corresponding author
Devyansh Nimodia, Department of Radiodiagnosis, Datta Meghe Institute of Medical Sciences, Sawangi, Wardha, Maharashtra, India (drdevyansh24@gmail.com)