Skin nodules revealing leukemia: observation of a 3-month-old infant

A 3-month-old boy, with no notable pathological history, was brought to the emergency with a history of incessant cry and stool with blood. The diagnosis of intussusception is made after ultrasound. After surgical reduction, exploration found a mesenteric node with a hyperplastic character on the anatomopathological study. The postoperative time was simple, and the child was seen in consultation 15 days after discharge. The examination notes dermo-hypodermic lumps on the trunk, back and testicles, an abdominal ultrasound is requested returning with gastric thickening, periportal infiltration and testicles suggesting lymphoma. The biopsy of the belly lump showed infiltrated hypodermis, microscopically, the tumor cells were round. The cytoplasm was scarce. The nuclei were round, oval or focally irregular, and the mitosis was visible. The neoplasms were positive for Pax5, CD45, CD79 by immunohistochemical staining, which suggests leukemia or lymphoma. The blood count is normal, bone aspiration confirmed the final diagnosis of ALL-B with chloromas. The child receives chemotherapy according to the care protocol of the unfavorable risk group, with a follow-up of 12 months.